| Status | 已發表Published |
| Insulin and Insulin-like growth factors modulates cardiac differentiation through PI3K and casein kinase cascades in human pluripotent stem cells | |
Yang, Y. ; Ren, Z.; Song, C.; Liu, W. ; Long, Y.; Chen, G.
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| 2018-09-23 | |
| Source Publication | From Stem Cells to Human Development Abstract Book
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| Abstract | Insulin and insulin-like growth factor (IGF) play essential roles in stem cell pluripotency and proliferation. Insulin suppresses cardiac differentiation, but the details of the molecular regulation are unclear. We observe that the early exposure to insulin and IGF suppress spontaneous cardiac differentiation. Subsequently, we show that IGF expression increases during cardiac differentiation. We demonstrate that IGF modulation significantly affect epicardial and cardiac cell fates. Further study shows that PI3K and casein kinase are the main downstream targets of insulin/IGF pathway in cardiac differentiation. |
| Keyword | Insulin IGF hESC pluripotency |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 47200 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Chen, G. |
| Recommended Citation GB/T 7714 | Yang, Y.,Ren, Z.,Song, C.,et al. Insulin and Insulin-like growth factors modulates cardiac differentiation through PI3K and casein kinase cascades in human pluripotent stem cells[C], 2018. |
| APA | Yang, Y.., Ren, Z.., Song, C.., Liu, W.., Long, Y.., & Chen, G. (2018). Insulin and Insulin-like growth factors modulates cardiac differentiation through PI3K and casein kinase cascades in human pluripotent stem cells. From Stem Cells to Human Development Abstract Book. |
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