| Status | 已發表Published |
| Stage-wise keratinocyte differentiation with defined factors in human embryonic stem cells | |
Zhong, H. ; Ren, Z.; Miao, K.; Liu, W. ; Chuxia, D.; Chen, G.
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| 2018-09-23 | |
| Source Publication | From Stem Cells to Human Development Abstract Book
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| Abstract | Skin is the largest organ of human body, and most skin cells are keratinocytes. In animal models, WNT and NOTCH pathways are essential in keratinocyte differentiation, but their functions are not implicated in the current differentiation procedures in human embryonic stem cell culture. In this report, we establish a keratinocyte differentiation procedure in chemically defined cell culture conditions and demonstrate that WNT and NOTCH modulation is critical for early cell determination in epidermal lineage. This study establishes a platform to study keratinocyte cell fate determination in vitro, and also provides an efficient protocol to produce keratinocytes for disease models and applications. |
| Keyword | Human embryonic stem cell keratinocyte differentiation TP63 Epidermal Extraembryonic lineage |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 47196 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Chen, G. |
| Recommended Citation GB/T 7714 | Zhong, H.,Ren, Z.,Miao, K.,et al. Stage-wise keratinocyte differentiation with defined factors in human embryonic stem cells[C], 2018. |
| APA | Zhong, H.., Ren, Z.., Miao, K.., Liu, W.., Chuxia, D.., & Chen, G. (2018). Stage-wise keratinocyte differentiation with defined factors in human embryonic stem cells. From Stem Cells to Human Development Abstract Book. |
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