THYROID HORMONE ENHANCES CELL CULTURE CAPACITY AND PROMOTES LINEAGE SPECIFIC DIFFERENTIATION IN HUMAN EMBRYONIC STEM CELLS

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	THYROID HORMONE ENHANCES CELL CULTURE CAPACITY AND PROMOTES LINEAGE SPECIFIC DIFFERENTIATION IN HUMAN EMBRYONIC STEM CELLS
	Deng, C.; Zhang, Z.; Ren, Z.; Godoy-Parejo, C.; Liu, W.; Chen, G.
	2019-06-26
Source Publication	ISSCR 2019 Annual Meeting
Abstract	Thyroid hormone triiodothyronine (T3) improves early embryo development in vitro. Human embryonic stem cells (hESCs) are derived from the inner cell mass of blastocyst, but little it known how the does hESCs modulated by T3. In this report, we use hESCs to show that T3 improves different aspects of stem cell culture. T3 stimulates oxidative phosphorylation and activates mitochondrial activities. T3 promotes cell survival and passaging efficiency at high density, and boosts culture consistency. Further research shows that T3 promotes FGF/ERK pathway to maintain pluripotency, and also boost cell adhesion and survival in suspension culture. For in vitro differentiation, T3 inhibit neural crest differentiation but promote pituitary gland differentiation, T3 also promote mesoderm and extraembryonic differentiation. This study demonstrates T3 can enhance hESC culture and is a useful supplement to advance stem cell applications.
Keyword	Thyroid hormone hESC differentiation
Language	英語English
The Source to Article	PB_Publication
PUB ID	47181
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Chen, G.
Recommended Citation GB/T 7714	Deng, C.,Zhang, Z.,Ren, Z.,et al. THYROID HORMONE ENHANCES CELL CULTURE CAPACITY AND PROMOTES LINEAGE SPECIFIC DIFFERENTIATION IN HUMAN EMBRYONIC STEM CELLS[C], 2019.
APA	Deng, C.., Zhang, Z.., Ren, Z.., Godoy-Parejo, C.., Liu, W.., & Chen, G. (2019). THYROID HORMONE ENHANCES CELL CULTURE CAPACITY AND PROMOTES LINEAGE SPECIFIC DIFFERENTIATION IN HUMAN EMBRYONIC STEM CELLS. ISSCR 2019 Annual Meeting.

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