As the supply chain of food around the world has become more and more globalized and complicated, food safety issue has attracted considerable concern owing to the widespread pollution of the whole ecosystem and the extent of their impact on the well-being of human beings. Correspondingly, a variety of analysis approaches to detecting and even adsorbing contaminants in food have been extensively explored and investigated. Among them, Metal-Organic Frameworks (MOFs) as potential versatile sensing materials have been utilized in the construction of multitude of sensing platforms with excellent performance to monitor different pollutants of food, including pesticide residues, heavy metals, mycotoxins and so on. Herein, we briefly introduce the progress of the MOFs-based sensing techniques, and then present the typical contributions of representative sensing platforms in detection of pesticides, heavy metals and other contaminants. Finally, we evaluate and discuss the future perspectives and challenges of MOFs in food contaminant analysis.