Identification of tube morphogenesis genes in the C. elegans gonad system by RNAi screens

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Status	已發表Published
	Identification of tube morphogenesis genes in the C. elegans gonad system by RNAi screens
	Khan, A.; Wu, F.; Ying, R.; Gobel, V.; Zhang, H.
	2016-06-01
Source Publication	7th Asia-Pacific C. elegans Meeting Abstract Book
Abstract	Tubes are the building blocks of many internal organs in multicellular organisms, and defects in tube morphogenesis cause devastating diseases. To understand the molecular mechanisms of tube formation, our previous screen in C. elegans has identified hundreds of molecules required for tubulogenesis in intestine and/or excretory canals. Here in this study, we are aiming to identify genes involved in the formation and the size and shape regulation of a different tubular organ - the spermatheca - through a genome-wide RNAi screen. The hermaphrodite spermatheca is composed of 24 epithelial cells organized into an accordion-like stretchable tube that contains sperm. Its ability to expand during the passage of oocytes demonstrates unique resilience and flexibility of a tubular epithelium. The spermatheca develops post-embryonically starting from late L3/early L4 stages, providing the following advantages for a tube morphogenesis screen: (1) it can be specifically targeted with conditional RNAi for those embryonic and larval lethal genes, conveniently bypassing their functions in growth regulation, signaling, transcriptional regulation, and cell fate determination; (2) it will help to recover non-lethal genes, whose knockdown may hardly affect the development of intestine and excretory
Keyword	Tube morphogenesis C. elegans RNAi screen gonad system
Language	英語English
The Source to Article	PB_Publication
PUB ID	21273
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Zhang, H.
Recommended Citation GB/T 7714	Khan, A.,Wu, F.,Ying, R.,et al. Identification of tube morphogenesis genes in the C. elegans gonad system by RNAi screens[C], 2016.
APA	Khan, A.., Wu, F.., Ying, R.., Gobel, V.., & Zhang, H. (2016). Identification of tube morphogenesis genes in the C. elegans gonad system by RNAi screens. 7th Asia-Pacific C. elegans Meeting Abstract Book.

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