BRCAx familial breast cancer refers to the familial breast cancer without known germline predispositions; they account for 60–65% of familial breast cancer cases (1). BRCAx familial breast cancer is not a homologous disease entity but composed of more homogenous subtypes, as reflected by the differences in histologic grade, morphology, status of ER, PR and HER2/neu, basal phenotype (CK5/6, CK14, SMA, EGFR), and genetic sequences (2–12). Precise classification of BRCAx familial breast cancer into more homogeneous subtypes can allow better understanding genetic causes and developing targeted clinical treatment for the disease. Due to the lack of specific genetic markers, however, it is difficult to classify the disease further. Clinically, BRCAx breast cancer is diagnosed and treated as a single disease (13).