Coptidis rhizome and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Coptidis rhizome and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity
	Meng, F.; Wu, Z.; Yin, Z.; Lin, L.; Wang, R.; Zhang, Q. W.
	2018-05-07
Source Publication	Chinese Medicine
ISSN	1749-8546
Pages	13-13
Abstract	Background Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment of various diseases including bacillary dysentery, typhoid, tuberculosis, epidemic cerebrospinal meningitis, empyrosis, pertussis, and other illnesses. Methods A literature survey was conducted via SciFinder, ScieneDirect, PubMed, Springer, and Wiley databases. A total of 139 selected references were classified on the basis of their research scopes, including chemical investigation, quality evaluation and pharmacological studies. Results Many types of secondary metabolites including alkaloids, lignans, phenylpropanoids, flavonoids, phenolic compounds, saccharides, and steroids have been isolated from CR. Among them, protoberberine-type alkaloids, such as berberine, palmatine, coptisine, epiberberine, jatrorrhizine, columamine, are the main components of CR. Quantitative determination of these alkaloids is a very important aspect in the quality evaluation of CR. In recent years, with the advances in isolation and detection technologies, many new instruments and methods have been developed for the quantitative and qualitative analysis of the main alkaloids from CR. The quality control of CR has provided safety for pharmacological applications. These quality evaluation methods are also frequently employed to screen the active components from CR. Various investigations have shown that CR and its main alkaloids exhibited many powerful pharmacological effects including anti-inflammatory, anti-cancer, anti-diabetic, neuroprotective, cardioprotective, hypoglycemic, anti-Alzheimer and hepatoprotective activities. Conclusion This review summarizes the recent phytochemical investigations, quality evaluation methods, the biological studies focusing on CR as well as its main alkaloids.
Keyword	Coptidis rhizoma Coptis genus Phytochemistry Quality evaluation Pharmacological effects
Language	英語English
The Source to Article	PB_Publication
PUB ID	36256
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.; Zhang, Q. W.
Recommended Citation GB/T 7714	Meng, F.,Wu, Z.,Yin, Z.,et al. Coptidis rhizome and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity[J]. Chinese Medicine, 2018, 13-13.
APA	Meng, F.., Wu, Z.., Yin, Z.., Lin, L.., Wang, R.., & Zhang, Q. W. (2018). Coptidis rhizome and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity. Chinese Medicine, 13-13.
MLA	Meng, F.,et al."Coptidis rhizome and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity".Chinese Medicine (2018):13-13.

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