Caesalpinaxin, a cassane-type diterpenoids with a 21-carbon core skeleton from the seeds of caesalpinia minax possessing pro-angiogenetic property

UM > Institute of Chinese Medical Sciences

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	Caesalpinaxin, a cassane-type diterpenoids with a 21-carbon core skeleton from the seeds of caesalpinia minax possessing pro-angiogenetic property
	Lou, R.; Xu, Y.; Chen, J.; Feng, Z.; Lin, L.
	2021-10-09
Source Publication	Bioorganic Chemistry
ISSN	0045-2068
Pages	105426-105426
Abstract	A novel cassane-type diterpenoid, caesalpinaxin (1), was isolated from the seeds of Caesalpinia minax Hance. The structure of caesalpinaxin was established by means of spectroscopic techniques (NMR, HR-ESIMS, UV and IR). The absolute configuration of caesalpinaxin was determined by quantum chemical calculations of its theoretical electronic circular dichroism (ECD) spectrum. Caesalpinaxin is the first cassane-type diterpenoid with 21 carbons core skeleton, containing an unusual δ-lactone ring. A plausible biosynthetic pathway was proposed for compound 1. Furthermore, caesalpinaxin was tested for the pro-angiogenetic activity on human umbilical vein endothelial cells (HUVECs). The results indicated that this compound significantly stimulated migration and tuber formation through enhancing the level of vascular endothelial growth factor (VEGF). Thus, caesalpinaxin might be applied in accelerating wound healing.
Keyword	Cassalpinia minax Fabaceae Caesalpinaxin ECD Angiogenesis
Language	英語English
The Source to Article	PB_Publication
PUB ID	62494
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Lin, L.
Recommended Citation GB/T 7714	Lou, R.,Xu, Y.,Chen, J.,et al. Caesalpinaxin, a cassane-type diterpenoids with a 21-carbon core skeleton from the seeds of caesalpinia minax possessing pro-angiogenetic property[J]. Bioorganic Chemistry, 2021, 105426-105426.
APA	Lou, R.., Xu, Y.., Chen, J.., Feng, Z.., & Lin, L. (2021). Caesalpinaxin, a cassane-type diterpenoids with a 21-carbon core skeleton from the seeds of caesalpinia minax possessing pro-angiogenetic property. Bioorganic Chemistry, 105426-105426.
MLA	Lou, R.,et al."Caesalpinaxin, a cassane-type diterpenoids with a 21-carbon core skeleton from the seeds of caesalpinia minax possessing pro-angiogenetic property".Bioorganic Chemistry (2021):105426-105426.

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