¬¬Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	¬¬Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance
	Shen, S.; Liao, Q.; Pan, R.; Lin, L.
	2019-10-16
Source Publication	Abstract of XIII International Symposium on the Chemistry of Natural Compounds
Abstract	Skeletal muscle is the predominant site for glucose disposal and fatty acid consumption. Emerging evidences have indicated the crosstalk between adipose and skeletal muscle is critical in maintaining insulin sensitivity and lipid homeostasis. The current study was designed to investigate whether myricanol (MY) improves insulin sensitivity and alleviates adiposity through modulating skeletal muscle-adipose crosstalk. MY was found to increase mitochondrial quantity and function through activating AMP-activated protein kinase, resulting in reduced lipid accumulation and enhanced insulin-stimulated glucose uptake, in PA-treated C2C12 myobutes. Furthermore, MY stimulated irisin production and secretion from myotubes to reduce lipid content in 3T3-L1 adipocytes. In high fat diet-fed mice, MY treatment alleviated adiposity and insulin resistance through enhancing lipid utilization and irisin production in skeletal muscle, and subsequently browning of inguinal fat. Taken together, our results implicated that MY modulates skeletal muscle-adipose crosstalk, to alleviate adiposity, improve insulin sensitivity, and stimulate browning of adipose tissue. MY might be a potential candidate for treating insulin resistance and obesity.
Keyword	myricanol myotubes irisin mitochondira browning
Language	英語English
The Source to Article	PB_Publication
PUB ID	49991
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Lin, L.
Recommended Citation GB/T 7714	Shen, S.,Liao, Q.,Pan, R.,et al. ¬¬Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance[C], 2019.
APA	Shen, S.., Liao, Q.., Pan, R.., & Lin, L. (2019). ¬¬Myricanol modulates skeletal muscle-adipose crosstalk to alleviate high fat diet-induced obesity and insulin resistance. Abstract of XIII International Symposium on the Chemistry of Natural Compounds.

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