Α-Mangostin ameliorates aging related adipose tissue inflammation and metabolic disorders

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Α-Mangostin ameliorates aging related adipose tissue inflammation and metabolic disorders
	Li, D.; Liu, Q.; Liu, J.; Wang, Y. T.; Lin, L.
	2018-07-01
Source Publication	中國化學會第12屆天然有機化學學術會議摘要
Abstract	Obesity in the elderly individuals is increasing at an alarming rate; and low-grade inflammation in adipose tissue contributes to the onset and development of metabolic disorders, such as insulin resistance and type 2 diabetes. α-mangostin was the main xanthone in mangosteen (Garcinia mangostana), which has been used in traditional medicine for treatment of various inflammatory diseases. The present study was designed to test the hypothesis that α-mangostin could alleviate age-related adipose tissue inflammation. Firstly, α-mangostin ameliorated lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 macrophages, and tumor necrosis factor α (TNF-α) mediated inflammation in 3T3-L1 adipocytes, through inhibiting the mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) activation, and promoting sirtuin3 (SIRT3) expression. In addition, α-mangostin blocked RAW264.7 macrophages migration towards 3T3-L1 adipocytes in cell co-culture system. Next, α-mangostin attenuated inflammatory responses in LPS-induced acute inflammatory mice model. Lastly, we recruited a cohort of young (4 months old) and aged (20 months old) mice, and found α-mangostin reduced aging-related inflammation in adipose tissue. α-Mangostin reduced the levels of pro-inflammatory cytokines and chemoattractants, inhibited macrophage infiltration into adipose tissue, and reversed the age-related shift towards pro-inflammatory macrophages, through suppressing the activation of MAPKs and NF-κB pathways. In aged mice, α-mangostin decreased the mass of epididymal fat, improved insulin sensitivity and ameliorated liver steatosis. Overall, the above results demonstrated that α-mangostin might represent a novel therapeutic agent for treatment of aging-related chronic adipose tissue inflammation and metabolic disorders.
Keyword	Mangoteen xanthones adipose tissue inflammation aging
Language	英語English
The Source to Article	PB_Publication
PUB ID	38404
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Lin, L.
Recommended Citation GB/T 7714	Li, D.,Liu, Q.,Liu, J.,et al. Α-Mangostin ameliorates aging related adipose tissue inflammation and metabolic disorders[C], 2018.
APA	Li, D.., Liu, Q.., Liu, J.., Wang, Y. T.., & Lin, L. (2018). Α-Mangostin ameliorates aging related adipose tissue inflammation and metabolic disorders. 中國化學會第12屆天然有機化學學術會議摘要.

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