A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression
	Lee, T. O.; Lam, IPY; Chow, BKC
	2008-06-20
Source Publication	Journal of Molecular Neuroscience
ISSN	0895-8696
Pages	125-131
Abstract	Secretin is a peptide hormone playing multiple functions in the brain–gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals.
Keyword	Secretin VNTR promoter
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	51101
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Chow, BKC
Recommended Citation GB/T 7714	Lee, T. O.,Lam, IPY,Chow, BKC. A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression[J]. Journal of Molecular Neuroscience, 2008, 125-131.
APA	Lee, T. O.., Lam, IPY., & Chow, BKC (2008). A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression. Journal of Molecular Neuroscience, 125-131.
MLA	Lee, T. O.,et al."A functional variable number of tandem repeats is located at the 5’ flanking region of the human secretin gene plays a down regulatory role in expression".Journal of Molecular Neuroscience (2008):125-131.

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