A new type of bioactive calcium phosphate cement with an excellent property of anti-washout for bone replacement was prepared by using cellulose as additive and non-aqueous solvent as liquid. The property of anti-washout, physical chemistry performances, hydration products and the biocompatibility were investigated. The results indicate that the improved CPC has an excellent anti-washout property and can be easily shaped as well as injected. The addition of the cellulose does not have obviously effect on the setting time and compressive strength of the CPC hardened body. The cultural cells are attached, dispersed and preferentially proliferated on the surface of the improved CPC. The fabricated biomaterials can be used as the filler of the bone defect or vertebroplasty or kyphoplasty in micro invasive surgery.